Hi Josh,
Yes, it works with 3D and 2D.
Check your email spam folder. Actually you probably have a message from a Gmail account, too. I usually follow up from a Gmail account 24 hours after responding from tony (at) pixelcrushers.com case in a customer's inbox has inadvertently filed the first email into a spam folder. I'll paste my email reply here:
Sure, the Dialogue System's integration works with TDE 3D as well as 2D, no scripting required. I included a 2D example scene in the integration, but the setup is the same for 3D. The Dialogue System also handles quests, although I didn't put a quest example in the example scene. Feel free to try out the
evaluation version first if you haven't bought the Dialogue System yet.
Here are some useful documentation links:
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Manual
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Tutorials
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TopDown Engine Integration Instructions